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Wolves is one of the most recent releases, a 5-reel slot machine with a healthy RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.<br><br>The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be used to determine the cause-effect relationship of an intervention and its effects. They should not, however be used to replace explanation studies.<br><br>The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial, including the recruitment process, the design and delivery of the intervention, and monitoring.<br><br>The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.