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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of research design, like recruitment and consent as well as adherence to the use of commonly available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, 프라그마틱 슬롯 무료 which used different investigators and participants from different geographic areas. This type of heterogeneity, that is crucial for pragmatic trials to be valid and reduce bias in results is also essential. However, too much heterogeneity can result in issues with the design of the trial.
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The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They can be used to determine the causality of an intervention and its results. However, they should not be used as a substitute for explanation trials.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, and the follow-up.
There is a growing trend in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of studies were conducted in primary care settings.