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Pragmatic trials are studies designed to inform real-world clinical practice. They are often characterized by a focus on the practical aspects of the research design, like the recruitment and consent process as well as adherence to the use of routinely available equipment.
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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also reduces bias in the results. However, too much heterogeneity, can cause problems with the design of the trial.
Pragmatic Play is also a major player on the live casino market, providing a wide selection of table games like as Blackjack and Roulette in various versions. Pragmatic Play's live studios in Romania and Malta provide a genuine gambling experience for players, as well as a wide range of virtual betting options. The company has also developed numerous interactive game shows that make gambling online enjoyable. Some of these shows are hosted live and some are hosted by famous personalities from the field.
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Legality
Pragmatic Play is known for its top-quality games and for providing a superior user experience. Its software can be used on mobile devices and in multiple languages. It has earned itself the status of one of the leading casino gaming platforms despite its relative infancy. Wolves is one of the most recent releases that is a 5-reel slot machine with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by policymakers and practitioners to guide their decisions. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. However, they should not, be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study, including recruitment, design, delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.