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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are often characterized as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A practical trial that employs different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can cause problems with the design of the trial.
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In addition to their mobile-friendly slot machines, Pragmatic Play also offers tables games and live dealer casinos. The company is licensed and is regulated by various regulatory bodies which include the Malta Gaming Authority and UK Gambling Commission. The games are supported by the latest encryption technology and the security team is always available to assist players solve any issues they might have.
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Most Pragmatic Play games are available for free, so you can play them before you decide to play them for real money. These games can be played on any device including tablets, desktops and mobile phones. You can play them anywhere you have an internet connection. They are easy to navigate. Some Pragmatic Play websites even let you test your luck in motion by playing a test mode. This lets you familiarize yourself with game rules and features before playing for real money.
Legality
Pragmatic Play has gained a reputation for offering high-quality games and a superior user experience. Its software is designed to work with mobile devices and is compatible with various languages. Despite its relative youth, it has already established itself as a top gaming platform for casinos. Wolves is one of the most recent releases which is a five-reel slot machine with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually commissioned by practitioners and policy makers to guide their decision-making. They can also be a great method to determine the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for explanation trials.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study, including the recruitment process, the design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to remember that the majority were conducted in primary-care settings.