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Pragmatic trials are trials designed to provide information for the real-world practice of clinical. They are typically described by their focus on practical aspects of design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographical regions. This type of heterogeneity is required for practical trials to be valid and also reduces the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.
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Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software can be used on mobile devices and in a variety of languages. It has been recognized as one of the top casino gaming platforms despite its relative infancy. Wolves is one of its latest releases that is a 5-reel slot machine with a hefty RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually ordered by policymakers and practitioners in order to guide their decisions. They are also a good way to identify the cause-effect relationship between the intervention and its effects. However, they shouldn't be used as a substitute for explanation studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, and monitoring.
The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatics. It is important to note, however, that the majority of studies were conducted in primary-care settings.