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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described by their focus on practical aspects of design, including recruitment and consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from various geographical areas. This kind of heterogeneity is required for pragmatic trials to be valid and reduces the chance of bias in the results. However too much heterogeneity could lead to issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They can be used to determine the cause-effect relationship of an intervention and its results. However, they shouldn't be used as a substitute for explanation trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or 무료슬롯 프라그마틱 if they are an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials that inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study, including the recruitment, design, and delivery of the intervention and follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.